转录因子
细胞生物学
生物
利基
细胞命运测定
干细胞巢
拟南芥
干细胞
祖细胞
遗传学
生态学
基因
突变体
作者
Jian Zeng,Xiang Li,Qiang Ge,Zhicheng Dong,Linjie Luo,Zhaoxia Tian,Zhong Zhao
出处
期刊:Nature plants
[Springer Nature]
日期:2021-08-05
卷期号:7 (9): 1276-1287
被引量:20
标识
DOI:10.1038/s41477-021-00985-z
摘要
Stem cell populations in all multicellular organisms are situated in a niche, which is a special microenvironment that defines stem cell fate. The interplay between stem cells and their niches is crucial for stem cell maintenance. Here, we show that an endogenous stress-related signal (ESS) is overrepresented in the shoot stem cell niche under natural growth conditions, and the vast majority of known stem-cell-specific and niche-specific genes responded to stress signals. Interference with the ESS in the stem cell niche by blocking ethylene signalling impaired stem cell maintenance. Ethylene-insensitive 3 (EIN3), the key transcription factor in ethylene signalling, directly actives the expression of the stress hub transcription factor AGAMOUS-LIKE 22 (AGL22) in the stem cell niche and relays ESS signals to the WUSCHEL/CLAVATA network. Our results provide a mechanistic framework for ESS signalling control of the stem cell niche and demonstrate that plant stem cells are maintained by a native stress microenvironment in vivo. Could plant stem cells be maintained by a constitutive endogenous stress? It is shown here that components of the ethylene signalling pathway are involved in Arabidopsis shoot stem cell maintenance, through the transcription factor AGL22.
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