Global Prevalence of Young-Onset Dementia

痴呆 医学 人口 心理信息 人口学 荟萃分析 奇纳 老年学 儿科 梅德林 心理干预 精神科 疾病 内科学 环境卫生 社会学 政治学 法学
作者
Stevie Hendriks,Kirsten Peetoom,Christian Bakker,Wiesje M. van der Flier,Janne M. Papma,Raymond T.C.M. Koopmans,Frans R.J. Verhey,Marjolein de Vugt,Sebastian Köhler,Adrienne Withall,Juliette L. Parlevliet,Özgül Uysal‐Bozkir,Roger C. Gibson,Susanne M. Neita,T. Rune Nielsen,Lise Cronberg Salem,Jenny Nyberg,Marcos Antônio Lopes,Jacqueline C. Dominguez,Ma. Fe De Guzman,Alexander Egeberg,Kylie Radford,Tony Broe,Mythily Subramaniam,Edimansyah Abdin,Amalia C. Bruni,Raffaele Di Lorenzo,Kate Smith,Leon Flicker,Merel O. Mol,Maria Basta,Doris Yu,Golden Mwakibo Masika,Maria Skaalum Petersen,Luís Ruano
出处
期刊:JAMA Neurology [American Medical Association]
卷期号:78 (9): 1080-1080 被引量:155
标识
DOI:10.1001/jamaneurol.2021.2161
摘要

Reliable prevalence estimates are lacking for young-onset dementia (YOD), in which symptoms of dementia start before the age of 65 years. Such estimates are needed for policy makers to organize appropriate health care.To determine the global prevalence of YOD.The PubMed, Embase, CINAHL, and PsycInfo databases were systematically searched for population-based studies on the prevalence of YOD published between January 1, 1990, and March 31, 2020.Studies containing data on the prevalence of dementia in individuals younger than 65 years were screened by 2 researchers for inclusion in a systematic review and meta-analysis.Prevalence estimates on 5-year age bands, from 30 to 34 years to 60 to 64 years, were extracted. Random-effects meta-analyses were conducted to pool prevalence estimates. Results were age standardized for the World Standard Population. Heterogeneity was assessed by subgroup analyses for sex, dementia subtype, study design, and economic status based on the World Bank classification and by meta-regression.Prevalence estimates of YOD for 5-year age bands.A total of 95 unique studies were included in this systematic review, of which 74 with 2 760 379 unique patients were also included in 5-year age band meta-analyses. Studies were mostly conducted in Europe and in older groups in Asia, North America, and Oceania. Age-standardized prevalence estimates increased from 1.1 per 100 000 population in the group aged 30 to 34 years to 77.4 per 100 000 population in the group aged 60 to 64 years. This gives an overall global age-standardized prevalence of 119.0 per 100 000 population in the age range of 30 to 64 years, corresponding to 3.9 million people aged 30 to 64 years living with YOD in the world. Subgroup analyses showed prevalence between men and women to be similar (crude estimates for men, 216.5 per 100 000 population; for women, 293.1 per 100 000 population), whereas prevalence was lower in high-income countries (crude estimate, 663.9 per 100 000 population) compared with upper-middle-income (crude estimate, 1873.6 per 100 000 population) and lower-middle-income (crude estimate, 764.2 per 100 000 population) countries. Meta-regression showed that age range (P < .001), sample size (P < .001), and study methodology (P = .02) significantly influenced heterogeneity between studies.This systematic review and meta-analysis found an age-standardized prevalence of YOD of 119.0 per 100 000 population, although estimates of the prevalence in low-income countries and younger age ranges remain scarce. These results should help policy makers organize sufficient health care for this subgroup of individuals with dementia.PROSPERO CRD42019119288.
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