环状RNA
小RNA
肝细胞癌
医学
病态的
核糖核酸
癌症研究
长非编码RNA
生物信息学
肿瘤科
病理
基因
生物
遗传学
作者
Ying Wang,Xinyi Zhou,Xiang‐Yun Lu,Keda Chen,Hang Yao
标识
DOI:10.1016/j.hbpd.2021.08.013
摘要
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide with high mortality. The incidence of HCC is increasing in China. Abnormal activation of glucose-6-phosphate dehydrogenase (G6PD) exists in all malignant tumors, including HCC, and is closely related to the development of HCC. In addition, the differential expression of non-coding RNAs is closely related to the development of HCC. This systematic review focuses on the relationship between G6PD, HCC, and non-coding RNA, which form the basis for the circRNA/miRNA/G6PD axis in HCC. The circular RNA (circRNA)/microRNA (miRNA)/G6PD axis is involved in development of HCC. We proposed that non-coding RNA molecules of the circRNA/miRNA/G6PD axis may be novel biomarkers for the pathological diagnosis, prognosis, and targeted therapy of HCC.
科研通智能强力驱动
Strongly Powered by AbleSci AI