NIR as a “trigger switch” for rapid phase change, on-demand release, and photothermal synergistic antibacterial treatment with chitosan-based temperature-sensitive hydrogel

Temperature-sensitive hydrogels have shown good performances as wound dressing owing to their ability to fill wounds in the liquid state and to release drugs in a solid state. However, their treatment efficiency is restricted by the phase transition time. In this study, we developed a photothermal synergistic chitosan-based temperature-sensitive hydrogel, h-EGF-CS/β-GP-MPDA@Cip, with the unique properties of rapid phase transition and drug release under near-infrared light (NIR). High antibacterial efficiency was achieved when we covered infected mice wounds with hydrogels. The local high temperature produced under NIR illumination not only accelerated the formation of a porous gel to release the loaded drug on-demand, but also dissolved bacteria, achieving synergistic anti-bacterial treatment. In addition, the healing cycle of wounds could be significantly shortened by adding human epidermal growth factor (h-EGF) in the hydrogel. Overall, the developed temperature-sensitive hydrogel could utilise NIR as a "trigger switch" for on-demand drug release and photothermal-enhanced antibacterial treatment during the rapid phase change process.