焦虑
默认模式网络
重性抑郁障碍
认知
神经科学
焦虑症
临床心理学
心理学
静息状态功能磁共振成像
精神科
医学
作者
Peter Zhukovsky,Michael Wainberg,Milos Milic,Shreejoy J. Tripathy,Benoit H. Mulsant,Daniel Felsky,Aristotle N. Voineskos
标识
DOI:10.1073/pnas.2204433119
摘要
The extent of shared and distinct neural mechanisms underlying major depressive disorder (MDD), anxiety, and stress-related disorders is still unclear. We compared the neural signatures of these disorders in 5,405 UK Biobank patients and 21,727 healthy controls. We found the greatest case–control differences in resting-state functional connectivity and cortical thickness in MDD, followed by anxiety and stress-related disorders. Neural signatures for MDD and anxiety disorders were highly concordant, whereas stress-related disorders showed a distinct pattern. Controlling for cross-disorder genetic risk somewhat decreased the similarity between functional neural signatures of stress-related disorders and both MDD and anxiety disorders. Among cases and healthy controls, reduced within-network and increased between-network frontoparietal and default mode connectivity were associated with poorer cognitive performance (processing speed, attention, associative learning, and fluid intelligence). These results provide evidence for distinct neural circuit function impairments in MDD and anxiety disorders compared to stress disorders, yet cognitive impairment appears unrelated to diagnosis and varies with circuit function.
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