The calcium channel terminator: hasta la vista pain

Chronic pain remains a major burden and is difficult to treat. N-type calcium channels may be a suitable therapeutic target for analgesics, and a new study from Colecraft and colleagues utilizes a clever new way to modulate their expression to achieve therapeutic benefits in preclinical models of neuropathic pain. Chronic pain remains a major burden and is difficult to treat. N-type calcium channels may be a suitable therapeutic target for analgesics, and a new study from Colecraft and colleagues utilizes a clever new way to modulate their expression to achieve therapeutic benefits in preclinical models of neuropathic pain. a vector which can be used for viral expression of exogenous proteins in neurons and other types of cells. an anatomical structure that contains the cell bodies of sensory neurons that innervate the skin and internal organs. a network of membranes inside a cell through which proteins and other molecules pass after synthesis. a class of drug molecules that were originally derived from γ-aminobutyric acid (GABA) receptor ligands, some of which are used clinically to treat chronic pain and which interact with the Cavα2δ subunit of high-voltage-activated calcium channels. a family of voltage-gated calcium channels that are activated by large membrane depolarization; these include the N-type (Cav2.2), P/Q-type (Cav2.1), R-type (Cav2.3), and L-type (Cav1) calcium channels. into the sole of the foot. recombinant variable domains of antibodies that contain only their heavy chain, and that can be exogenously expressed in target cells. sensory neurons that detect nociceptive (painful) peripheral stimuli such as heat, cold, mechanical force, tissue inflammation, and acidity. a calcium channel that is typically expressed in presynaptic nerve terminals and contributes to neurotransmitter release. the outer membrane of a cell. injury to the sciatic nerve in which the common peroneal and tibial nerve branches are injured, whereas the sural nerve branch is spared, leading to persistent neuropathic pain in rodents, as demonstrated by the laboratory of Clifford Woolf in 2000. a family of calcium channels that are activated by small membrane depolarizations and which encompass three different Cav3 channels. a post-translational modification in which a ubiquitin ligase enzyme attaches small ubiquitin groups or chains of ubiquitin moieties to target lysine residues on protein substrates, and which then act as a degradation signal.