TRPV1型
慢性疼痛
瞬时受体电位通道
背根神经节
医学
痛觉过敏
伤害
神经科学
神经病理性疼痛
药理学
针灸科
体感系统
基因剔除小鼠
脊髓
长时程增强
受体
病理
内科学
生物
替代医学
作者
Hsien-Yin Liao,Ming‐Chia Lin,Yi‐Wen Lin
出处
期刊:DOAJ: Directory of Open Access Journals - DOAJ
日期:2022-04-01
卷期号:25 (4): 451-459
被引量:1
标识
DOI:10.22038/ijbms.2022.60121.13327
摘要
Tissue injury in peripheral sites can result in long-term potentiation in nociceptive neurons and surrounding glial cells, potentially resulting in the development of chronic inflammatory pain (CIP). Acupoint injection (AI) is similar to Western phototherapy, which injects solutions at specific sites to mitigate chronic pain. AI has shown greater benefits compared with acupuncture. In this study, we examined the therapeutic effect and explored the underlying mechanisms of AI in mice CIP model.We injected thrice complete Freund's adjuvant (CFA) into the mouse's hind paw to induce CIP.We found that, after two weeks, CFA injection significantly induced mechanical and thermal hyperalgesia which were attenuated by AI treatment. Transient receptor potential V1 (TRPV1) channels and associated molecules were all increased in CIP in mice dorsal root ganglion (DRG), spinal cord (SC), thalamus, and somatosensory cortex (SSC). The aforementioned molecules were mitigated in AI and Trpv1 knockout mice. Furthermore, Iba1-positive cells (microglial marker) were also potentiated and shared a similar tendency with TRPV1.These findings suggest that AI can alleviate chronic pain by reducing TRPV1 overexpression in both neuronal and microglial cells. Our results suggest new potential therapeutic targets for AI in chronic pain.
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