MPTP公司
线粒体
线粒体通透性转换孔
生物能学
线粒体基质
细胞生物学
厌氧糖酵解
程序性细胞死亡
生物
化学
癌症研究
糖酵解
生物化学
细胞凋亡
新陈代谢
酶
神经科学
胞浆
多巴胺能
多巴胺
作者
Ling Zhang,Yi Liu,Rou Zhou,Baoyu He,Wenjun Wang,Bin Zhang
标识
DOI:10.3389/fonc.2022.939588
摘要
Cyclophilin D (CypD) is a peptide-proline cis-trans isomerase (PPIase) distributed in the mitochondrial matrix. CypD regulates the opening of the mitochondrial permeability conversion pore (mPTP) and mitochondrial bioenergetics through PPIase activity or interaction with multiple binding partners in mitochondria. CypD initially attracted attention due to its regulation of mPTP overopening-mediated cell death. However, recent studies on the effects of CypD on tumors have shown conflicting results. Although CypD has been proven to promote the aerobic glycolysis in tumor cells, its regulation of malignant characteristics such as the survival, invasion and drug resistance of tumor cells remains controversial. Here, we elaborate the main biological functions of CypD and its relationships with tumor progression identified in recent years, focusing on the dual role of CypD in tumors.
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