已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Association of Methylene Blue Dosing With Hemodynamic Response for the Treatment of Vasoplegia

医学 亚甲蓝 丸(消化) 麻醉 血流动力学 平均动脉压 心脏指数 血流动力学反应 血压 外科 心率 心输出量 内科学 催化作用 光催化 化学 生物化学
作者
Benjamin Hohlfelder,Aaron Douglas,Lu Wang,Matthew Wanek,Seth R. Bauer
出处
期刊:Journal of Cardiothoracic and Vascular Anesthesia [Elsevier BV]
卷期号:36 (9): 3543-3550 被引量:3
标识
DOI:10.1053/j.jvca.2022.04.003
摘要

Objectives To compare the hemodynamic response of methylene blue dosing regimens (bolus v bolus plus infusion) for the treatment of vasoplegia. Design A retrospective cohort analysis. Setting A single-center academic medical center. Participants Patients who underwent cardiac surgery at Cleveland Clinic and received methylene blue between 2016 and 2019. Patients were excluded from the analysis if methylene blue was initiated >48 hours after surgery, if the cardiac index was <2.0 L/min/m2, or if they returned to the operating room for postoperative hemorrhage. Interventions Methylene blue bolus-only regimens versus bolus plus continuous infusion methylene blue regimens. Measurements and Main Results The primary outcome was vasopressor requirement over 48 hours (1, 3, 6, 12, 24, and 48 hours) after methylene blue initiation. Other hemodynamic outcomes evaluated included the rate of methylene blue response, mean arterial pressure (MAP), and systemic vascular resistance (SVR) values over time. In total, 44 patients were included in the analysis, 33 of whom only received a methylene blue bolus. Vasopressor requirements at baseline were 95 (95% CI: 70-122) µg/min norepinephrine equivalent (NE) in the bolus-only group and 100 (86-130) µg/min in the infusion group. Vasopressor requirements decreased at each time point in both groups and were similar throughout (hour 1 mean [95% CI] NE, bolus 79 [67-91] µg/min v bolus plus infusion 84 [63-104] µg/min; p = 0.71). MAP, SVR, and rates of methylene blue response were similar between groups at all time points. Clinical outcomes also were similar between groups. Conclusions The addition of a methylene blue continuous infusion did not significantly improve hemodynamic response. Bolus-only dosing of methylene blue may be sufficient for the treatment of vasoplegia after cardiac surgery. To compare the hemodynamic response of methylene blue dosing regimens (bolus v bolus plus infusion) for the treatment of vasoplegia. A retrospective cohort analysis. A single-center academic medical center. Patients who underwent cardiac surgery at Cleveland Clinic and received methylene blue between 2016 and 2019. Patients were excluded from the analysis if methylene blue was initiated >48 hours after surgery, if the cardiac index was <2.0 L/min/m2, or if they returned to the operating room for postoperative hemorrhage. Methylene blue bolus-only regimens versus bolus plus continuous infusion methylene blue regimens. The primary outcome was vasopressor requirement over 48 hours (1, 3, 6, 12, 24, and 48 hours) after methylene blue initiation. Other hemodynamic outcomes evaluated included the rate of methylene blue response, mean arterial pressure (MAP), and systemic vascular resistance (SVR) values over time. In total, 44 patients were included in the analysis, 33 of whom only received a methylene blue bolus. Vasopressor requirements at baseline were 95 (95% CI: 70-122) µg/min norepinephrine equivalent (NE) in the bolus-only group and 100 (86-130) µg/min in the infusion group. Vasopressor requirements decreased at each time point in both groups and were similar throughout (hour 1 mean [95% CI] NE, bolus 79 [67-91] µg/min v bolus plus infusion 84 [63-104] µg/min; p = 0.71). MAP, SVR, and rates of methylene blue response were similar between groups at all time points. Clinical outcomes also were similar between groups. The addition of a methylene blue continuous infusion did not significantly improve hemodynamic response. Bolus-only dosing of methylene blue may be sufficient for the treatment of vasoplegia after cardiac surgery.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
momo发布了新的文献求助10
刚刚
刚刚
至秦完成签到,获得积分10
1秒前
2秒前
2秒前
4秒前
头头啊头头啊完成签到,获得积分10
4秒前
Notdodead应助畅通无阻采纳,获得10
4秒前
至秦发布了新的文献求助30
4秒前
张兔子发布了新的文献求助10
6秒前
科研通AI2S应助132采纳,获得30
7秒前
wimper发布了新的文献求助10
10秒前
wimper完成签到,获得积分10
15秒前
15秒前
17秒前
小药同学发布了新的文献求助10
18秒前
19秒前
Pu Chunyi发布了新的文献求助10
22秒前
漂亮白枫发布了新的文献求助10
22秒前
程程发布了新的文献求助10
24秒前
27秒前
27秒前
刺闰土的猹完成签到,获得积分10
27秒前
星辰大海应助漂亮白枫采纳,获得10
28秒前
学术圈边缘派遣员完成签到,获得积分10
28秒前
29秒前
30秒前
小肉包发布了新的文献求助10
33秒前
33秒前
33秒前
35秒前
35秒前
过时的毛豆完成签到,获得积分10
36秒前
J.发布了新的文献求助10
37秒前
程程完成签到,获得积分10
38秒前
SciGPT应助Xangel采纳,获得10
38秒前
Tewd完成签到,获得积分10
39秒前
领导范儿应助pokexuejiao采纳,获得20
41秒前
Tewd发布了新的文献求助10
42秒前
45秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989811
求助须知:如何正确求助?哪些是违规求助? 3531927
关于积分的说明 11255560
捐赠科研通 3270706
什么是DOI,文献DOI怎么找? 1805035
邀请新用户注册赠送积分活动 882181
科研通“疑难数据库(出版商)”最低求助积分说明 809190