蛋白质水解
癌症研究
髓系白血病
癌基因
转录因子
白血病
抄写(语言学)
生物
基因
髓样
细胞生物学
计算生物学
遗传学
生物化学
细胞周期
哲学
酶
语言学
作者
Adam I. Green,George M. Burslem
标识
DOI:10.1016/j.chembiol.2022.03.005
摘要
Preventing uncontrolled gene expression is a powerful therapeutic strategy for the treatment of cancers. In this issue of Cell Chemical Biology, Xu et al. (2022) describe a series of proteolysis targeting chimeras that induce the degradation of NSD3 and suppress cMyc-related oncogene transcription in a model of acute myeloid leukemia.
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