锰
材料科学
纳米颗粒
纳米材料
纳米技术
催化作用
过氧化氢酶
铁氧体(磁铁)
磁共振成像
化学
酶
生物化学
医学
放射科
复合材料
冶金
作者
Susana Carregal‐Romero,A.B. Miguel-Coello,Lydia Martínez‐Parra,Yolanda Martí-Mateos,Pablo Hernansanz‐Agustín,Yilian Fernández‐Afonso,Sandra Plaza‐García,Lucía Gutiérrez,María del Mar Muñoz‐Hernández,Juliana Carrillo‐Romero,Marina Piñol-Cancer,Pierre Lecante,Zuriñe Blasco-Iturri,Lucía Fadón,Ana C. Almansa‐García,Marco Möller,Dorleta Otaegui,José Antonio Enrı́quez,Hugo Groult,Jesús Ruíz‐Cabello
出处
期刊:Small
[Wiley]
日期:2022-03-08
卷期号:18 (16)
被引量:33
标识
DOI:10.1002/smll.202106570
摘要
Abstract Manganese ferrite nanoparticles display interesting features in bioimaging and catalytic therapies. They have been recently used in theranostics as contrast agents in magnetic resonance imaging (MRI), and as catalase‐mimicking nanozymes for hypoxia alleviation. These promising applications encourage the development of novel synthetic procedures to enhance the bioimaging and catalytic properties of these nanomaterials simultaneously. Herein, a cost‐efficient synthetic microwave method is developed to manufacture ultrasmall manganese ferrite nanoparticles as advanced multimodal contrast agents in MRI and positron emission tomography (PET), and improved nanozymes. Such a synthetic method allows doping ferrites with Mn in a wide stoichiometric range (Mn x Fe 3‐ x O 4 , 0.1 ≤ x ≤ 2.4), affording a library of nanoparticles with different magnetic relaxivities and catalytic properties. These tuned magnetic properties give rise to either positive or dual‐mode MRI contrast agents. On the other hand, higher levels of Mn doping enhance the catalytic efficiency of the resulting nanozymes. Finally, through their intracellular catalase‐mimicking activity, these ultrasmall manganese ferrite nanoparticles induce an unprecedented tumor growth inhibition in a breast cancer murine model. All of these results show the robust characteristics of these nanoparticles for nanobiotechnological applications.
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