Postoperative prophylactic intermittent noninvasive ventilation versus usual postoperative care for patients at high risk of pulmonary complications: a multicentre randomised trial

医学 优势比 外科 置信区间 呼吸衰竭 随机对照试验 入射(几何) 心胸外科 麻醉 内科学 光学 物理
作者
Stanislas Abrard,Emmanuel Rineau,Valérie Seegers,Nathalie Lebrec,Cyril Sargentini,Audrey Jeanneteau,Emmanuelle Longeau,Sigrid Caron,Jean-Christophe Callahan,Nicolas Chudeau,François Beloncle,Sigismond Lasocki,Denis Dupoiron
出处
期刊:BJA: British Journal of Anaesthesia [Elsevier BV]
卷期号:130 (1): e160-e168 被引量:8
标识
DOI:10.1016/j.bja.2021.11.033
摘要

Pulmonary complications are an important cause of morbidity and mortality after surgery. We evaluated the clinical effectiveness of noninvasive ventilation (NIV) in preventing postoperative acute respiratory failure.This is an open, multicentre randomised trial that included patients at high risk of postoperative pulmonary complications after elective or semi-urgent surgery with an Assess Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) score ≥45. Patients were randomly assigned to intermittent prophylactic face-mask NIV for 6-8 h day-1 or usual postoperative care. The primary outcome was in-hospital acute respiratory failure within 7 days after surgery. Patients who underwent surgery and postoperative extubation were included in the modified intended-to-treat analysis. Results are presented as n (%) and odds ratios (ORs) with 95% confidence intervals.Between November 2017 and October 2019, 266 patients were randomised and 253 included in the main analysis. Of these, 203 (80.2%) were male with a mean age of 68 (11) yr and an ARISCAT score of 53 (6); 237 subjects (93.7%) underwent cardiac or thoracic surgery. There were 125 patients allocated to prophylactic NIV and 128 to usual care. Unplanned treatment termination occurred in 58 subjects in the NIV group, which was linked to NIV discomfort for 36 subjects. There was no difference in the incidence of the primary outcome of postoperative acute respiratory failure between treatment groups (NIV: 30 of 125 subjects [24.0%] vs usual care: 35 of 128 subjects [27.3%]; OR 0.97 [0.90-1.04]; P=0.54).Prophylactic NIV was difficult to implement after high-risk surgery because of low patient compliance. Prophylactic NIV did not prevent acute respiratory failure.NCT03629431 and EudraCT 2017-001011-36.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
hhhh完成签到,获得积分0
刚刚
WeiBao完成签到,获得积分10
1秒前
zzzzzzzp完成签到,获得积分10
2秒前
李心澍完成签到,获得积分10
2秒前
葫芦家二娃完成签到,获得积分10
4秒前
陈文文完成签到 ,获得积分10
4秒前
dddd完成签到,获得积分10
4秒前
优雅的雁凡完成签到,获得积分10
4秒前
文静静静完成签到 ,获得积分10
4秒前
shijin135完成签到,获得积分10
5秒前
彪壮的绮烟完成签到,获得积分10
6秒前
grs完成签到,获得积分10
6秒前
dis完成签到,获得积分10
7秒前
刘雅彪完成签到 ,获得积分10
7秒前
正经大善人完成签到,获得积分10
8秒前
英俊的铭应助医学小王采纳,获得10
8秒前
8秒前
芝儿完成签到 ,获得积分10
9秒前
9秒前
gaoxiaogao完成签到,获得积分10
9秒前
在水一方应助Rae采纳,获得10
10秒前
耍酷的翠曼完成签到,获得积分10
11秒前
司徒乌完成签到,获得积分10
11秒前
thisky完成签到,获得积分10
12秒前
lilian发布了新的文献求助10
12秒前
DyLan完成签到,获得积分0
12秒前
共享精神应助明明明采纳,获得10
13秒前
渴望者完成签到,获得积分20
13秒前
13秒前
默然的歌完成签到 ,获得积分10
13秒前
星星完成签到,获得积分10
13秒前
David完成签到 ,获得积分10
13秒前
Evan123完成签到,获得积分10
14秒前
空格TNT完成签到 ,获得积分10
15秒前
JIE发布了新的文献求助10
16秒前
小彭完成签到,获得积分10
17秒前
17秒前
Akim应助超帅含烟采纳,获得10
17秒前
Oo。完成签到,获得积分10
17秒前
18秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968603
求助须知:如何正确求助?哪些是违规求助? 3513420
关于积分的说明 11168029
捐赠科研通 3248900
什么是DOI,文献DOI怎么找? 1794540
邀请新用户注册赠送积分活动 875187
科研通“疑难数据库(出版商)”最低求助积分说明 804676