Ameliorative patterns of grey matter in patients with first-episode and treatment-naïve schizophrenia

楔前 颞下回 颞中回 灰质 顶叶下小叶 库尼乌斯 精神分裂症(面向对象编程) 额中回 颞上回 心理学 舌回 额上回 听力学 额下回 后扣带 神经认知 额内侧回 神经科学 精神科 认知 医学 颞叶 白质 癫痫 磁共振成像 功能磁共振成像 放射科
作者
Mingli Li,Wei Deng,Yinfei Li,Liansheng Zhao,Xiaohong Ma,Hua Yu,Xiaojing Li,Yajing Meng,Qiang Wang,Xiangdong Du,Pak C. Sham,Lena Palaniyappan,Tao Li
出处
期刊:Psychological Medicine [Cambridge University Press]
卷期号:53 (8): 3500-3510 被引量:3
标识
DOI:10.1017/s0033291722000058
摘要

Abstract Background Grey matter (GM) reduction is a consistent observation in established late stages of schizophrenia, but patients in the untreated early stages of illness display an increase as well as a decrease in GM distribution relative to healthy controls (HC). The relative excess of GM may indicate putative compensatory responses, though to date its relevance is unclear. Methods 343 first-episode treatment-naïve patients with schizophrenia (FES) and 342 HC were recruited. Multivariate source-based morphometry was performed to identify covarying ‘networks' of grey matter concentration (GMC). Neurocognitive scores using the Cambridge Neuropsychological Test Automated Battery (CANTAB) and symptom burden using the Positive and Negative Symptoms Scale (PANSS) were obtained. Bivariate linear relationships between GMC and cognition/symptoms were studied. Results Compared to healthy subjects, FES had prominently lower GMC in two components; the first consists of the anterior insula, inferior frontal gyrus, anterior cingulate and the second component with the superior temporal gyrus, precuneus, inferior/superior parietal lobule, cuneus, and lingual gyrus. Higher GMC was seen in adjacent areas of the middle and superior temporal gyrus, middle frontal gyrus, inferior parietal cortex and putamen. Greater GMC of this component was associated with lower duration of untreated psychosis, less severe positive symptoms and better performance on cognitive tests. Conclusions In untreated stages of schizophrenia, both a distributed lower and higher GMC is observable. While the higher GMC is relatively modest, it occurs across frontoparietal, temporal and subcortical regions in association with reduced illness burden suggesting a compensatory role for higher GMC in the early stages of schizophrenia.

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