Anti‐diabetic effect of mixed raw food containing germinated barley and wheat with less side‐effect in SD rats and db/db mice model (829.15)

The blood glucose lowering effect and side‐effect reducing potential of the mixed raw food (Saengshik) which contains germinated barley extract (GBE) and germinated wheat extract (GWE) were investigated in SD rats and db/db mice model. Saengshik was prepared by mixing different kinds of raw food with GBE and GWE. According to the results of blood glucose, HbA1c, insulin, HOMA‐IR analysis, Saengshik with GBE and GWE can not only lower the blood glucose level, but also improve insulin resistance both in SD rats and db/db mice. Saengshik with GBE and GWE significantly reduced total glyceride (TG) and total cholesterol (TC) in db/db mouse compared to the control group. In addition, the several symptoms of side effects including enlarged cecum, reduced intestinal transport activity and increased starch contents in feces were notably improved by Saengshik feeding compared to the Acarbose group in SD rats and db/db mice. Our results indicate that Saengshik with GBE and GWE may have a potential to be served as useful dietary strategy for diabetes.