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Regulation of Drug Release by Tuning Surface Textures of Biodegradable Polymer Microparticles

PLGA公司 材料科学 聚合物 化学工程 分散性 乙二醇 可生物降解聚合物 药物输送 生物相容性 乳状液 PEG比率 表面粗糙度 纳米技术 高分子化学 纳米颗粒 复合材料 工程类 经济 冶金 财务
作者
Mubashir Hussain,Jun Xie,Zaiyan Hou,Khurram Shezad,Jiangping Xu,Ke Wang,Yujie Gao,Lei Shen,Jintao Zhu
出处
期刊:ACS Applied Materials & Interfaces [American Chemical Society]
卷期号:9 (16): 14391-14400 被引量:74
标识
DOI:10.1021/acsami.7b02002
摘要

Generally, size, uniformity, shape, and surface chemistry of biodegradable polymer particles will significantly affect the drug-release behavior in vitro and in vivo. In this study, uniform poly(d,l-lactic-co-glycolide) (PLGA) and PLGA-b-poly(ethylene glycol) (PLGA-b-PEG) microparticles with tunable surface textures were generated by combining the interfacial instabilities of emulsion droplet and polymer-blending strategy. Monodisperse emulsion droplets containing polymers were generated through the microfluidic flow-focusing technique. The removal of organic solvent from the droplets triggered the interfacial instabilities (spontaneous increase in interfacial area), leading to the formation of uniform polymer particles with textured surfaces. With the introduction of homopolymer PLGA to PLGA-b-PEG, the hydrophobicity of the polymer system was tailored, and a qualitatively different interfacial behavior of the emulsion droplets during solvent removal was observed. Uniform polymer particles with tunable surface roughness were thus generated by changing the ratio of PLGA-b-PEG in the polymer blends. More interestingly, surface textures of the particles determined the drug-loading efficiency and release kinetics of the encapsulated hydrophobic paclitaxel, which followed a diffusion-directed drug-release pattern. The polymer particles with different surface textures demonstrated good cell viability and biocompatibility, indicating the promising role of the particles in the fields of drug or gene delivery for tumor therapy, vaccines, biodiagnostics, and bioimaging.
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