Expression of Platelet Collagen Receptor Glycoprotein VI in Coronary Heart Disease: Interaction between Platelets and Endothelial Cells

全球生产总值 血小板 血小板活化 血小板膜糖蛋白 CD63 医学 内科学 人口 流式细胞术 细胞粘附分子 P-选择素 免疫学 化学 生物化学 微泡 环境卫生 基因 小RNA
作者
Jian Shi,Ning Zhu,Jiwen Wang,Yu Wang,Zhaohong Geng,Suya Gao,Zhong-Yan Li
出处
期刊:Clinical Laboratory [Clinical Laboratory Publications]
卷期号:62 (07/2016) 被引量:3
标识
DOI:10.7754/clin.lab.2015.151123
摘要

1) To investigate the expression of platelet collagen receptor glycoprotein VI (GPVI) on the surface of platelets in patients with coronary heart disease (CHD). 2) To investigate the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the surface of endothelial cells after exposure to subjects' platelets.Platelets were extracted from blood samples of 97 subjects including 43 with acute coronary syndrome (ACS), 21 with stable angina pectoris (SAP), and 33 serving as controls in which CHD was excluded. Using flow cytometry, we measured the expression of GPVI and platelet degranulation markers CD62P and CD63. In addition we quantified expression of endothelial cell ICAM-1 and VCAM-1.A higher expression of platelet GPVI was observed in ACS compared with SAP and control groups. The expression level of platelet GPVI significantly correlated with CD62P and CD63 in the CHD population (r = 0.713 and 0.615, both p < 0.01). Significantly higher ICAM-1 expression was observed in endothelial cells after interaction with platelets from the ACS population. In the CHD subjects, the surface expression of platelet GPVI correlated with the level of ICAM-1 in endothelial cells (r = 0.371, p < 0.05).Platelet GPVI associated with platelet activation and endothelial inflammation is a vital index for predicting CHD occurrence and severity.

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