槲皮素
绿原酸
视网膜
一氧化氮合酶
体内
氧化应激
化学
一氧化氮
生物化学
血红素加氧酶
药理学
生物
血红素
抗氧化剂
酶
食品科学
有机化学
生物技术
作者
Yong Wang,Liang Zhao,Chengtao Wang,Jimei Hu,Xiaoxuan Guo,Di Zhang,Wei Wu,Feng Zhou,Baoping Ji
标识
DOI:10.1016/j.jff.2017.02.034
摘要
The protective effect of quercetin and chlorogenic acid (CA) on visible light-induced retinal damage was investigated in pigmented rabbits. Quercetin and CA effectively suppressed the levels of oxidative stress markers increased by light exposure and significantly increased the levels of heme oxygenase-1 in retina (p < 0.05). The levels of inflammatory cytokines, including monocyte chemoattractant protein 1, interleukin (IL)-8, IL-1 β, tumour necrosis factor-alpha, cyclooxygenase 2 and inducible nitric oxide synthase in retinal tissues, were significantly reduced by quercetin and CA; additionally, quercetin significantly inhibited the expression of nuclear factor kappa B (p < 0.05). Moreover, photooxidative stress-induced changes in expression levels of apoptotic proteins and angiogenesis factors were regulated by quercetin and CA. Histological analysis revealed that the thickness of the outer nuclear layer was maintained by quercetin but not by CA. Results suggest that quercetin and CA play an important role in alleviating retinal degeneration.
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