Synthesis and Study of Analgesic and Anti-inflammatory Activities of Amide Derivatives of Ibuprofen

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs worldwide and represent a mainstay in the therapy of acute and chronic pain and inflammation. The traditional NSAIDs like ibuprofen (I) contain free carboxylic acid group which can produce gastrointestinal (GI) damage for long-term use. Keywords: Analgesic, anti-inflammatory, ibuprofen, NSAIDs, pharmacological heterocyclic amides.