Chemistry of Propargyldicobalt Cations Recent Developments in the Nicholas and Related Reactions

化学 炔丙基 反应性(心理学) 电泳剂 埃尼 选择性 戒指(化学) 有机化学 药物化学 计算化学 催化作用 医学 病理 替代医学
作者
James R. Green
出处
期刊:Current Organic Chemistry [Bentham Science Publishers]
卷期号:5 (7): 809-826 被引量:144
标识
DOI:10.2174/1385272013375247
摘要

The chemistry of propargyldicobalt cations, also known as the Nicholas reaction, is Reviewed, with a focus on the developments since 1995. Advances in the understanding of the fundamental properties, such as structure, stability, and reactivity, of both the hexacarbonyl complexes and those bearing other ligands are discussed. All reactions involving propargyl cation dicobalt complexes are covered, including those stemming from ionization of propargylic leaving groups and those created by electrophilic addition to enyne complexes. Migration reactions involving either initiation or termination by propargyl cation complexes are included, as are the genera-tion and reactions of propargyldicobalt radicals. Cyclization reactions employing these cations have received much attention, in cases with the alkynedicobalt unit located in both exocyclic and endocyclic positions, and these reports are described. Particular attention is paid to preparation of medium ring cycloalkyne complexes and their heterocyclic analogues. In addition, there is discussion of the progress in the in selectivity of these reactions, especially in terms of introduction of asymmetry at the propargylic site. Finally, recent applications of Nicholas reaction chemistry in the synthesis of natural products and Related compounds are reported. Keywords: Propargyldicobalt Cations, Nicholas reaction, Cyclization, heterocyclic analogues, natural products, REACTIONS OF ENYNE COMPLEXES, CYCLIZATION REACTIONS - EXOCYCLIC ALKYNES, SELECTIVITY-ASYMMETRIC SYNTHESIS, NICHOLAS REACTIONS, MIGRATIONS
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