医学
恶性肿瘤
转化研究
疾病
重症监护医学
食管鳞状细胞癌
靶向治疗
癌症
生物信息学
内科学
病理
生物
作者
Zachary Wilmer Reichenbach,Mary Grace Murray,Reshu Saxena,Daniel T. Farkas,Erika G. Karassik,Alena Klochkova,Kishan Patel,Caitlin M. Tice,Timothy M. Hall,Julie Gang,Henry P. Parkman,Sarah Ward,Marie Pier Tétreault,Kelly A. Whelan
出处
期刊:Advances in Cancer Research
日期:2019-01-01
卷期号:: 95-135
被引量:115
标识
DOI:10.1016/bs.acr.2019.05.004
摘要
Esophageal squamous cell carcinoma (ESCC) is among the most deadly forms of human malignancy characterized by late stage diagnosis, metastasis, therapy resistance and frequent recurrence. Clinical management of ESCC remains challenging and the disease presently lacks approved targeted therapeutics. However, emerging data from recent clinical and translational investigations hold great promise for future progress toward improving patient outcomes in this deadly disease. Here, we review current clinical perspectives in ESCC epidemiology, pathophysiology, and clinical care, highlighting recent advances with potential to impact ESCC prevention, diagnosis and management. We further provide an overview of recent translational investigations contributing to our understanding of the molecular mechanisms underlying ESCC development, progression and therapy response, including insights gained from genetic studies and various murine model systems. Finally, we discuss future perspectives in the clinical and translational realms, along with remaining hurdles that must be overcome to eradicate ESCC.
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