聚吡咯
光热治疗
纳米技术
材料科学
纳米尺度
纳米材料
药物输送
纳米复合材料
纳米颗粒
聚合物
聚合
复合材料
作者
Xuechao Cai,Xiaoran Deng,Zhongxi Xie,Yanshu Shi,Maolin Pang,Jun Lin
标识
DOI:10.1016/j.cej.2018.10.044
摘要
Nanoscale metal-organic frameworks (NMOFs) are promising porous nanomaterials for various applications, such as catalysis, biomedical imaging, drug delivery and cancer therapy etc. Especially when it comes to medical applications, downsizing of MOFs into nanoscale is the crucial requirement. Herein, liquid-solid-solution (LSS) method was used to prepare nano Fe-soc-MOF for the first time, and then we integrated the as-synthesized nanoscale Fe-soc-MOF with polypyrrole (PPy) to construct a multifunctional theranostic platform. The novel Fe-soc[email protected] core-shell nanohybrids can be triggered by the 808 nm laser irradiation to produce photothermal effect for cancer therapy. The photothermal therapy (PTT) was performed both in vitro and in vivo. This work demonstrates the great potential of the MOF nanocomposites for cancer diagnosis and treatment.
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