生物相容性
牛血清白蛋白
伤口愈合
甲基丙烯酸酯
药物输送
生物医学工程
单体
自愈水凝胶
材料科学
丙烯酸
毒品携带者
化学
高分子化学
医学
外科
生物化学
聚合物
有机化学
作者
Dongmei Liu,Susu Zhao,Yujie Jiang,Chuanhui Gao,Yumin Wu,Yuetao Liu
标识
DOI:10.1016/j.eurpolymj.2023.111820
摘要
Hydrogels with good biocompatibility and the ability to maintain a moist environment at the wound site, as well as good drug-carrying capacity and slow-release properties, can be used as medical materials for wound dressings. Albumin is the primary plasma protein and the physiological carrier of a wide range of compounds, including drugs. To exploit the binding ability of albumin to drugs, we prepared bovine serum albumin-P (Acrylic acid-co-Acrylamide-co-N-Vinylpyrrolidone-co-Hydroxyethyl methacrylate-co-γ-(methacryloyloxy) propyltrimethoxysilane) double network hydrogels by copolymerizing BSA with various easy-to-polymerize monomers. The synthesized double network hydrogels can substantially improve the mechanical strength of natural protein-based hydrogels with a maximum stress of 1.17 MPa. Due to the good biocompatibility and stable drug release properties of BSA, in vitro evaluation in a mouse skin incision model showed that the hydrogels had a high wound closure effect, providing a feasible strategy for rapid skin wound healing.
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