自愈水凝胶
明胶
极限抗拉强度
弹性模量
甲基丙烯酸酯
复合材料
材料科学
弹性(物理)
杨氏模量
丝素
丝绸
共聚物
化学
聚合物
高分子化学
生物化学
作者
Zengkai Wang,Xiaolu Song,Xiangming Li,Xiaoyang Yue,Shuai Hou,Lei Liu
标识
DOI:10.1021/acs.chemmater.2c02791
摘要
Regulating the mechanical performance of a material, especially for protein hydrogels, in situ from elasticity to plasticity and vice versa would be difficult but highly anticipated due to the diversity of promising applications. Herein, we proposed a strategy to prepare versatile hydrogels with tunable mechanical properties. It was demonstrated that we could rapidly prepare regenerated silk fibroin/gelatin (RSF/Gel) copolymer hydrogels by chemically modifying RSF by glycidyl methacrylate (RSF-MA) and gelatin by methacrylic anhydride (Gel-MA) under UV light in 60 s. Furthermore, the RSF/Gel hydrogels showed tunable mechanical properties by controlling the β-sheet content of SF, which can realize reversible switch between elasticity and plasticity in situ. The significant alteration of tensile stress at break and tensile elastic modulus at 10% strain was achieved with 720 times and 2000 times improvement from an elastic to plastic hydrogel. The compressive elastic modulus at 50% strain of a plastic hydrogel was improved to 3.6 MPa, which was 62 times higher than that of an elastic hydrogel. In addition, the performance of drug release of RSF/Gel hydrogel microneedles could be modulated by controlling the β-sheet content of SF, which could be a drug carrier and also be other promising biomaterials for a variety of biological and clinical applications.
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