聚苯胺
材料科学
纳米复合材料
石墨烯
电极
电化学气体传感器
检出限
纳米颗粒
氧化物
电化学
三元运算
纳米技术
生物分子
化学工程
聚合物
化学
复合材料
色谱法
计算机科学
工程类
物理化学
聚合
冶金
程序设计语言
作者
Vidhya C. Valsalakumar,Amala Shaliya Joseph,Juveena Piyus,Suni Vasudevan
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2023-04-10
卷期号:6 (10): 8382-8395
被引量:11
标识
DOI:10.1021/acsanm.3c00659
摘要
Modern clinical chemistry research has revealed a significant demand for materials that can be used in biomarker screening. Accordingly, we have developed a simple enzyme-free electrochemical sensor for the detection of l-Tyrosine (l-Tyr) based on the enhanced electrocatalytic activity of a novel ternary nanocomposite material. The nanocomposite was prepared by decorating zirconium dioxide (ZrO2) nanoparticles onto a polyaniline–graphene oxide composite, which was subsequently named as PGZ, incorporating the first letters from polyaniline, graphene oxide, and zirconium dioxide. Electrodes modified with the new material could selectively detect l-Tyr at physiological pH in the presence of common interfering biomolecules. Differential pulse voltammetric studies with the sensor showed a satisfactory linear response for l-Tyr in the range of 100 nM–250 μM and a very low detection limit of 2 nM. The modified electrode was conveniently fabricated, which displayed excellent sensitivity, selectivity, and reproducibility. It could also successfully detect the amino acid in human blood samples. The miniaturization of electrochemical assembly was performed by modifying the screen-printed electrode (SPE) with the PGZ composite, which may be further extended to the manufacture of devices for the highly sensitive and selective detection of l-Tyr in various biological samples.
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