医学
认知功能衰退
老年学
鹿特丹研究
执行职能
痴呆
认知
人口学
前瞻性队列研究
内科学
精神科
社会学
疾病
作者
Sara A. Galle,Jun Liu,Bruno Bonnechère,Najaf Amin,Maarten M Milders,Jan Berend Deijen,Erik J A Scherder,Madeleine L Drent,Trudy Voortman,M. Arfan Ikram,Cornelia M van Duijn
标识
DOI:10.1007/s10654-022-00902-4
摘要
Research on the association between physical inactivity and cognitive decline and dementia is dominated by studies with short-term follow-up, that might be biased by reverse causality. Investigate the long-term association between physical activity, cognition, and the rate of age-associated cognitive decline. We investigated the association between late-life physical activity and executive functioning and rate of decline of executive abilities during follow-up of up to 16 years, in 3553 participants of the prospective Rotterdam Study cohort. Measurement took place in 1997–1999, 2002–2004, 2009–2011, and 2014–2015. At baseline (age ± 72 years), higher levels of physical activity were associated with higher levels of executive functioning (adjusted mean difference = 0.03, 95% CI: 0.00 ; 0.06, p = 0.03). This difference remained intact up to 16 years of follow-up. The level of physical activity at baseline was unrelated to the rate of decline of executive abilities over time, in the whole group (adjusted mean difference in changetime*physical activity = 0.00, 95% CI: -0.00 ; 0.01, p = 0.31). However, stratification by APOE genotype showed that the accelerated decline of executive abilities observed in those with the ApoE-ε4 allele might be attenuated by higher levels of physical activity in late adulthood (ApoE-ε4 carriers: Btime*physical activity = 0.01, 95% CI: 0.00 ; 0.01, p = 0.03). Higher levels of physical activity in late adulthood are related to higher levels of executive functioning, up to 16 years of follow-up. Accelerated decline of executive abilities observed in those with the ApoE-ε4 allele might be mitigated by higher levels of physical activity.
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