Oxidative stress in neonatal lambs and its relation to health status and passive colostral immunity

氧化应激 免疫 氧化磷酸化 被动免疫 生物 免疫系统 生理学 免疫学 内分泌学 生物化学
作者
Erhan GÖKÇE,Pınar Cihan,Onur Atakişi,Ali Haydar KIRMIZIGÜL,Hidayet Metin ERDOĞAN
出处
期刊:Veterinary Immunology and Immunopathology [Elsevier BV]
卷期号:251: 110470-110470 被引量:8
标识
DOI:10.1016/j.vetimm.2022.110470
摘要

Oxidative stress (OS) related to birth in ruminants may increase susceptibility to diseases. However, information about the physiological changes related to OS in lambs is limited. This study was designed to evaluate changes in OS parameters [total antioxidant status (TAS, mmol Trolox Equiv./L), total oxidant status (TOS, μmol H2O2 Equiv./L)] and calculated oxidative stress index (OSi = TOS/TAS * 100, Arbitrary Unit) and its association with passive colostral transfer immunity and health status in neonatal Akkaraman crossbreed lambs. Control group of healthy lambs (n = 15) were blood sampled before (day 0) and after colostrum intake (on day 1, 2, 4, 7, 14 and 28) in order to evaluate the effect of colostrum intake on TAS, TOS and OSi over time. In addition, a group of lambs (experimental group, n = 60), based on their health status and different cut off value of IgG (mg/dL), was also blood sampled at 24 ± 1 h of colostrum ingestion to determine the relationship between OS parameters, IgG and health status. OS was evident at birth and gradually decreased in control group as TOS (days 0:8.06 ± 0.64, 1:7.05 ± 0.51, 2:5.23 ± 0.35, 4:5.05 ± 0.2, 7:5.13 ± 0.34, 14:3.75 ± 0.12 and 28:3.73 ± 0.15 μmol H2O2 Equiv./L), OSi (days 0: 8.35 ± 0.64, 1: 9.17 ± 1.05, 2:6.83 ± 0.6, 4:6.30 ± 0.20, 7:6.67 ± 0.59, 14:4.46 ± 0.19 and 28:4.87 ± 0.29 au) and TAS (days 0: 0.97 ± 0.02, 1:0.82 ± 0.04, 2:0.81 ± 0.05, 4:0.81 ± 0.02, 7:0.80 ± 0.03, 14:0.85 ± 0.02 and 28:0.79 ± 0.03 mmol Trolox Equiv./L) values changed over time. In the experimental group, the lambs died in the first week of the neonatal period had higher levels of TOS (10.3 ± 0.90 μmol H2O2 Equiv./L) and OSi (1.61 ± 0.22 au) than healthy ones (TOS:6.90 ± 0.36 μmol H2O2 Equiv./L, OSi:1.12 ± 0.11 au) (P < 0.001). The gradual decrease in OS in the neonatal period was accepted as a sign of improved antioxidant response. The study disclosed that deaths may develop when OS at birth is not balanced by suffıcient amount and quality of colostrum an important source of antioxidants such as enzymes and vitamins. The study presented may provide new information in the field of study on oxidative stress in neonatal lambs and help to prevent deaths in the first week of life. It can also be useful in developing preventive measures such as supplements of antioxidants to colostrum.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
carly完成签到 ,获得积分10
1秒前
颢懿完成签到 ,获得积分10
4秒前
量子星尘发布了新的文献求助10
5秒前
7秒前
ljc完成签到 ,获得积分10
8秒前
Java完成签到,获得积分10
12秒前
14秒前
鲤鱼安青完成签到 ,获得积分10
16秒前
16秒前
dollarpuff完成签到 ,获得积分10
19秒前
19秒前
mmmmmMM完成签到,获得积分10
26秒前
luckweb完成签到,获得积分10
32秒前
猫的毛完成签到 ,获得积分10
33秒前
nicky完成签到 ,获得积分10
34秒前
麦子完成签到 ,获得积分10
35秒前
35秒前
Wilson完成签到 ,获得积分10
36秒前
luckweb发布了新的文献求助10
36秒前
36秒前
40秒前
43秒前
传奇3应助wujiwuhui采纳,获得10
45秒前
开心寄松完成签到,获得积分10
47秒前
北宫完成签到 ,获得积分10
47秒前
wansida完成签到,获得积分10
51秒前
QXS完成签到 ,获得积分10
51秒前
52秒前
菠萝完成签到 ,获得积分10
52秒前
领导范儿应助Villanellel采纳,获得10
56秒前
wintersss完成签到,获得积分10
56秒前
尹尹发布了新的文献求助10
57秒前
量子星尘发布了新的文献求助10
59秒前
zzzzzz完成签到 ,获得积分10
1分钟前
坦率的枕头完成签到,获得积分10
1分钟前
XS_QI完成签到 ,获得积分10
1分钟前
与共发布了新的文献求助10
1分钟前
苑阿宇完成签到 ,获得积分10
1分钟前
yck1027完成签到,获得积分10
1分钟前
fatcat完成签到,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038066
求助须知:如何正确求助?哪些是违规求助? 3575779
关于积分的说明 11373801
捐赠科研通 3305584
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022