已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Efficacy and safety of potassium binders in the treatment of patients with chronic kidney disease and hyperkalemia

高钾血症 肾脏疾病 医学 内科学 疾病 重症监护医学 化学 有机化学
作者
Lingqiu Dong,Weidong Xu,Yi Deng,Jiaxing Tan,Wei Qin
出处
期刊:European Journal of Pharmacology [Elsevier BV]
卷期号:931: 175174-175174 被引量:15
标识
DOI:10.1016/j.ejphar.2022.175174
摘要

Gastrointestinal cation exchangers that can bind potassium in the gut, including sodium polystyrene sulfonate (SPS), calcium polystyrene sulfonate (CPS), patiromer and sodium zirconium cyclosilicate (SZC), are emerging medications for the treatment of hyperkalemia with chronic kidney disease (CKD). However, which might be the best alternative for patients with chronic kidney disease and hyperkalemia remains disputed. We performed this systematic review and network meta-analysis with the Bayesian approach to conduct direct and indirect comparisons among potassium binders regarding their efficacy and safety. The surface under the cumulative ranking curve analysis (SUCRA) was used to calculate the best intervention for each outcome. All four potassium binders had a promising effect regarding potassium reduction. SPS had favorable efficacy and safety for short-term use (MD: −0.94; 95% CIs: −1.4 to −0.48; SUCRA = 94.69%), but long-term treatment required strict dose control and assessment of gastrointestinal conditions. CPS had a positive effect on reducing potassium, and could especially maintain the serum potassium concentration in patients receiving renin-angiotensin-aldosterone system inhibitors (RAASi). Patiromer might reduce all-cause mortality in CKD patients with hyperkalemia and have a positive effect on potassium-lowering, though it had significant gastrointestinal adverse effects. SZC had a potassium-lowering effect in both the short-term and long-term, and can be a promising long-term treatment for the hyperkalemia in CKD patients, especially in combination with RAASi. These four potassium binders had their own advantages and disadvantages, and the medication should be selected according to the clinical situation of the patient.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
eric888应助干净的寒天采纳,获得200
2秒前
含蓄绿竹发布了新的文献求助10
2秒前
catsfat发布了新的文献求助10
3秒前
生动之云发布了新的文献求助10
4秒前
5秒前
fu发布了新的文献求助10
6秒前
谭小谭完成签到,获得积分10
8秒前
8秒前
17764715645完成签到 ,获得积分10
10秒前
10秒前
10秒前
张aa发布了新的文献求助10
13秒前
ctomit发布了新的文献求助20
13秒前
噗宝凹发布了新的文献求助10
14秒前
包子凯越完成签到,获得积分10
15秒前
16秒前
白鹭立雪完成签到,获得积分10
24秒前
念初发布了新的文献求助10
25秒前
搜集达人应助fu采纳,获得10
27秒前
28秒前
快乐的小叮当应助噗宝凹采纳,获得10
28秒前
充电宝应助Chi_bio采纳,获得10
28秒前
粥粥应助碧蓝的宝马采纳,获得10
28秒前
柚又完成签到 ,获得积分10
31秒前
小王顶呱呱完成签到 ,获得积分10
31秒前
33秒前
33秒前
可知发布了新的文献求助10
34秒前
34秒前
35秒前
rhei发布了新的文献求助20
36秒前
氯化氟完成签到 ,获得积分20
36秒前
zydong完成签到,获得积分10
37秒前
詹卫卫发布了新的文献求助10
38秒前
i3utter发布了新的文献求助10
39秒前
40秒前
深情安青应助AOPs采纳,获得10
40秒前
六年发布了新的文献求助30
41秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989918
求助须知:如何正确求助?哪些是违规求助? 3532013
关于积分的说明 11255831
捐赠科研通 3270829
什么是DOI,文献DOI怎么找? 1805053
邀请新用户注册赠送积分活动 882233
科研通“疑难数据库(出版商)”最低求助积分说明 809216