亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Making Waves: Intelligent phage cocktail design, a pathway to precise microbial control in water systems

水消毒 控制(管理) 水处理 生化工程 环境科学 环境工程 计算机科学 工程类 人工智能
作者
Bridget Hegarty
出处
期刊:Water Research [Elsevier]
卷期号:268: 122594-122594
标识
DOI:10.1016/j.watres.2024.122594
摘要

Current practices in water and wastewater treatment to control unwanted microbes have led to new problems, including health effects from disinfection byproducts, growth of opportunistic pathogens resistant to residual disinfectants (e.g., chlorine), and antibiotic resistance. These challenges are spurring interest in rethinking our practices of microbial control. Simultaneously, advances in molecular biology and computation power are driving renewed interest in using phages (viruses that infect bacteria) to precisely control microbial growth (aka, phage biocontrol). In this Making Waves article, I begin by reviewing the current state of research into phage cocktail design, emphasizing our limited understanding of the features of successful phage cocktails (combinations of multiple types of phages). I describe the state of modeling phage-bacteria interactions and underscore the need for increasing research efforts to predict phage cocktail success, a key gap slowing the application of phage biocontrol. I also detail how research must also focus on techniques for engineering more effective phages to offer a more rapid alternative to phage discovery from natural environments. In this way, phage cocktails comprised of phages with complementary infection strategies may be designed. The final area for increased research effort that I highlight is the need for phage cocktail design to account for possible unintended environmental effects, a risk that is increasingly acknowledged in phage ecology studies but mostly ignored by those developing phage biocontrol technologies. By focusing more research effort towards the areas necessary for intelligent phage cocktail design, we can accelerate the development of phage-based biocontrol in water systems and improve public health.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
精则养神完成签到,获得积分10
3秒前
deng完成签到 ,获得积分10
5秒前
16秒前
18秒前
zpj完成签到 ,获得积分10
18秒前
Raunio完成签到,获得积分10
22秒前
汶南完成签到 ,获得积分10
22秒前
飞翔的发布了新的文献求助10
23秒前
Doublelin完成签到,获得积分10
29秒前
Doublelin发布了新的文献求助10
32秒前
33秒前
科研通AI2S应助科研通管家采纳,获得10
37秒前
49秒前
平常的过客完成签到,获得积分10
58秒前
cuicui发布了新的文献求助10
59秒前
orixero应助Joven采纳,获得10
1分钟前
翟大有完成签到 ,获得积分0
1分钟前
cuicui完成签到,获得积分10
1分钟前
张宇漩完成签到 ,获得积分10
1分钟前
柔弱成危完成签到,获得积分20
1分钟前
脑洞疼应助zqh采纳,获得15
1分钟前
jjx1005完成签到 ,获得积分10
1分钟前
顾矜应助柔弱成危采纳,获得10
1分钟前
vion完成签到 ,获得积分10
1分钟前
1分钟前
2分钟前
SCT发布了新的文献求助10
2分钟前
L_x完成签到 ,获得积分10
2分钟前
lawrenceip0926完成签到,获得积分10
2分钟前
2分钟前
SCT完成签到,获得积分10
2分钟前
Joven发布了新的文献求助10
2分钟前
Joven完成签到,获得积分20
2分钟前
在水一方完成签到 ,获得积分0
2分钟前
2分钟前
Jasper应助小尾巴采纳,获得10
2分钟前
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
2分钟前
2分钟前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
Free Will in the Flesh 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3081568
求助须知:如何正确求助?哪些是违规求助? 2734319
关于积分的说明 7532599
捐赠科研通 2383865
什么是DOI,文献DOI怎么找? 1264044
科研通“疑难数据库(出版商)”最低求助积分说明 612506
版权声明 597577