亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Impact of T Cell Ratios on Survival in Pleural Mesothelioma: Insights from Tumor Microenvironment Analysis

FOXP3型 肿瘤微环境 免疫系统 CD8型 川地163 医学 CD3型 癌症研究 肿瘤浸润淋巴细胞 病理 免疫学 生物 巨噬细胞 生物化学 体外
作者
Laura V. Klotz,Andreas Weigert,Florian Eichhorn,Michael Allgäuer,Thomas Muley,Rajiv Shah,Rajkumar Savai,Martin Eichhorn,Hauke Winter
出处
期刊:Cancers [Multidisciplinary Digital Publishing Institute]
卷期号:16 (19): 3418-3418
标识
DOI:10.3390/cancers16193418
摘要

Background: Immunotherapy has significantly improved overall survival in patients with pleural mesothelioma, yet this benefit does not extend to those with the epithelioid subtype. Tumor growth is believed to be influenced by the immune response. This study aimed to analyze the tumor microenvironment to gain a better understanding of its influence on tumor growth. Methods: The tumor immune cell infiltration of 188 patients with pleural mesothelioma was characterized by multiplex immunofluorescence staining for CD3+ cells (CD3+), CD4+ cells (CD3+/CD4+), CD8+ cells (CD3+/CD8+), Treg (CD3+/CD4+/CD8-/CD163-/Foxp3+), PD1 cells (PD1+), and T helper cells (CD3+/CD4+/CD8-/CD163-/FoxP3-). The distribution of specific immune cells was correlated with clinical parameters. Results: A total of 188 patients with pleural mesothelioma (135 epithelioid, 9 sarcomatoid, 44 biphasic subtypes) were analyzed. The median age was 64.8 years. Overall survival was significantly longer in the epithelioid subtype than in the non-epithelioid subtype (p = 0.016). The presence of PD-L1 expression had a negative effect on overall survival (p = 0.041). A high ratio of CD4+ cells to regulatory T cells was associated with a significantly longer overall survival of more than 12 months (p = 0.015). The ratio of CD4+ cells to regulatory T cells retained its significant effect on overall survival in the multivariate analysis. Conclusions: Distinct differences in the T cell immune infiltrates in mesothelioma are strongly associated with overall survival. The tumor microenvironment could therefore serve as a source of prognostic biomarkers.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
五十一完成签到 ,获得积分10
5秒前
W1996发布了新的文献求助10
5秒前
优美的谷完成签到,获得积分10
7秒前
星辰大海应助婷子采纳,获得10
12秒前
依灵完成签到,获得积分10
16秒前
今后应助HMBB采纳,获得20
18秒前
小丸子完成签到 ,获得积分10
20秒前
22秒前
W1996完成签到,获得积分10
22秒前
婷子发布了新的文献求助10
27秒前
29秒前
linkin完成签到 ,获得积分10
30秒前
HMBB发布了新的文献求助20
34秒前
43秒前
1分钟前
灰色白面鸮完成签到,获得积分10
1分钟前
HMBB完成签到,获得积分10
1分钟前
HoraDorathy发布了新的文献求助10
1分钟前
CipherSage应助HoraDorathy采纳,获得10
1分钟前
新新新新新发顶刊完成签到 ,获得积分10
1分钟前
1分钟前
十有五发布了新的文献求助10
1分钟前
背完单词好睡觉完成签到 ,获得积分10
1分钟前
开霁完成签到 ,获得积分10
1分钟前
柏小霜完成签到 ,获得积分0
1分钟前
llxiaomianyang完成签到,获得积分10
1分钟前
章鱼小雷子完成签到,获得积分20
1分钟前
1分钟前
李爱国应助十有五采纳,获得10
1分钟前
1分钟前
CodeCraft应助外向不愁采纳,获得10
1分钟前
meow完成签到 ,获得积分10
1分钟前
2分钟前
2分钟前
2分钟前
大模型应助yyyalles采纳,获得30
2分钟前
xhcccc发布了新的文献求助10
2分钟前
万惜文发布了新的文献求助10
2分钟前
xhcccc完成签到,获得积分10
2分钟前
万惜文完成签到,获得积分10
2分钟前
高分求助中
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3963168
求助须知:如何正确求助?哪些是违规求助? 3509051
关于积分的说明 11145009
捐赠科研通 3242106
什么是DOI,文献DOI怎么找? 1791744
邀请新用户注册赠送积分活动 873127
科研通“疑难数据库(出版商)”最低求助积分说明 803622