定量配给
糖
糖尿病
环境卫生
医学
子宫内
消费(社会学)
疾病
经济
生物
内科学
内分泌学
食品科学
怀孕
医疗保健
经济增长
胎儿
社会科学
遗传学
社会学
作者
Tadeja Gračner,Claire Boone,Paul Gertler
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-10-31
标识
DOI:10.1126/science.adn5421
摘要
We examined the impact of sugar exposure within 1000 days since conception on diabetes and hypertension, leveraging quasi-experimental variation from the end of the United Kingdom’s sugar rationing in September 1953. Rationing restricted sugar intake to levels within current dietary guidelines, yet consumption nearly doubled immediately post-rationing. Using an event study design with UK Biobank data comparing adults conceived just before or after rationing ended, we found that early-life rationing reduced diabetes and hypertension risk by about 35% and 20%, respectively, and delayed disease onset by 4 and 2 years. Protection was evident with in-utero exposure and increased with postnatal sugar restriction, especially after six months when solid foods likely began. In-utero sugar rationing alone accounted for about one third of the risk reduction.
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