Application of Sulfonyl Fluorides in Organic Transformation

Abstract Sulfonyl fluorides, due to their balanced potential reactivity and stability as well as their compatibility with biological systems, have become important synthetic intermediates and building blocks in the fields of organic synthesis, drug discovery, and materials science. Especially after the report of sulfur(VI) fluoride exchange (SuFEx) chemistry by Sharpless and others, research on sulfonyl fluoride compounds and related compounds has increased significantly. This review summarizes application of sulfonyl fluorides in organic synthesis in the period 2014–2024, discussing different types of organic reactions, including C–X bond formation (including C–C, C–N, and C–F bond formation etc.), S–C bond formation, S–N bond formation, S–O bond formation, multicomponent ‘one-pot’ synthesis, and cyclization. 1 Introduction 2 Sulfonyl Fluorides Applied in C–X (C, N, F) Bond Formation 3 Sulfonyl Fluorides Applied in S–C Bond Formation 4 Sulfonyl Fluorides Applied in S–N Bond Formation 5 Sulfonyl Fluorides Applied in S–O Bond Formation 6 Sulfonyl Fluorides Applied in Multicomponent Reactions 7 Sulfonyl Fluorides Applied in Cyclizations 8 Conclusion and Perspective