医学
优势比
置信区间
心脏病学
心室重构
内科学
左心室肥大
肌肉肥大
向心性肥大
肥胖
体质指数
同心的
逻辑回归
血压
几何学
心力衰竭
数学
作者
Lili Yang,Menglong Li,Huan Wang,Wen Shu,Min Zhao,Costan G. Magnussen,Yifei Hu,Bo Xi
摘要
Abstract Aim To investigate the association between metabolically healthy obesity (MHO) and left ventricular geometric remodelling in Chinese children. Materials and Methods This cross‐sectional study used data from two population‐based samples in China, including 2871 children aged 6–11 years. Weight status was defined based on body mass index according to the World Health Organization growth chart. Metabolic status was defined based on the 2018 consensus‐based criteria proposed by Damanhoury et al . Obes Rev 2018; 19 :1476–1491 (blood pressure, lipids and glucose). Left ventricular geometric remodelling was determined as concentric remodelling, eccentric hypertrophy, and concentric hypertrophy. Multinomial logistic regression analysis was used to determine odds ratios (ORs) and 95% confidence intervals (CIs) for the association between categories of weight and metabolic status and left ventricular geometric remodelling. Results Compared with children with metabolically healthy normal weight, those with MHO had higher odds of left ventricular geometric remodelling, with adjusted ORs (95% CIs) of 2.01 (1.23–3.28) for concentric remodelling, 6.36 (4.03–10.04) for eccentric hypertrophy, and 17.07 (7.97–36.58) for concentric hypertrophy. Corresponding ORs (95% CIs) were 2.35 (1.47–3.75), 10.85 (7.11–16.55), and 18.56 (8.63–39.94), respectively, for children with metabolically unhealthy obesity. In contrast, metabolically unhealthy normal weight was not associated with higher odds of left ventricular geometric remodelling. Findings were consistent in sensitivity analyses that used different definitions of weight and metabolic status and left ventricular geometric remodelling. Conclusions Children with MHO had higher odds of left ventricular geometric remodelling than their metabolically healthy normal weight counterparts. Our findings suggest MHO may not be a benign condition for cardiac health in children.
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