纳米纤维
自愈
伤口愈合
收缩(语法)
材料科学
复合数
自愈水凝胶
生物医学工程
复合材料
医学
外科
高分子化学
病理
内科学
替代医学
作者
Yakun Huang,Meilin Song,Xianchao Li,Yanran Du,Zhongfei Gao,Yu-Qing Zhao,Chengbo Li,Huanhuan Yan,Xiumei Mo,Chun‐Hua Wang,Gui‐Ge Hou,Xianrui Xie
标识
DOI:10.1016/j.mtbio.2024.101214
摘要
Bacterial infections and long-term inflammation cause serious secondary damage to chronic diabetic wounds and hinder the wound healing processes. Currently, multifunctional hydrogels have shown promising effects in chronic wound repair. However, traditional hydrogels only keep the wound moist and protect it from bacterial infection, and cannot provide mechanical force to contract the wound edges to achieve facilitated wound closure. Here, an asymmetric composite dressing was created by combining biaxially oriented nanofibers and hydrogel, inspired by the double-layer structure of the traditional Chinese medicinal plaster patch, for managing chronic wounds. Specifically, electrospun Poly-(lactic acid-co-trimethylene carbonate) (PLATMC) nanofibers and methacrylate gelatin (GelMa) hydrogel loaded with Epinecidin-1@chitosan (Epi-1@CS) nanoparticles are assembled as the temperature-responsive self-contracting nanofiber/hydrogel (TSNH) composite dressing. The substrate layer of PLATMC nanofibers combines topological morphology with material properties to drive wound closure through temperature-triggered contraction force. The functional layer of GelMa hydrogel is loaded with Epi-1@CS nanoparticles that combine satisfactory cytocompatibility, and antioxidant, anti-inflammatory, and antibacterial properties. Strikingly,
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