肝肠循环
生药学
化学
传统医学
生物
胆汁酸
生物活性
生物化学
医学
体外
作者
Guoying Zhang,Wenjing Jia,Liying Liu,Luya Wang,Jiyu Xu,Jihong Tao,Mingkai Xu,Min Yue,Huiqin Luo,Ping Hai,Huilan Yue,Dejun Zhang,Xiaohui Zhao
标识
DOI:10.1016/j.jep.2024.118870
摘要
The incidence of cholestatic liver disease (CLD), which is primarily marked by abnormal bile acids (BAs) metabolism and can result in significant hepatic injury, is rising. Nevertheless, there remains a lack of effective treatments and drugs in clinical practice. Silphium perfoliatum L. (SP) is rich in various structural types of caffeoylquinic acid (CQA) compounds, and it is a traditional herb of North American Indians with hepatobiliary therapy effects. However, its therapeutic effect and mechanism of action on CLD have never been studied.
科研通智能强力驱动
Strongly Powered by AbleSci AI