失调
生物
炎症
抗生素
免疫学
微生物学
肠道菌群
作者
Olaf Perdijk,Alana Butler,Matthew Macowan,Roxanne Chatzis,Edyta Bulanda,R. Drummond Grant,Nicola Harris,Tomasz P. Wypych,Benjamin J. Marsland
出处
期刊:Immunity
[Elsevier]
日期:2024-07-01
被引量:2
标识
DOI:10.1016/j.immuni.2024.06.010
摘要
Antibiotic use in early life disrupts microbial colonization and increases the risk of developing allergies and asthma. We report that mice given antibiotics in early life (EL-Abx), but not in adulthood, were more susceptible to house dust mite (HDM)-induced allergic airway inflammation. This susceptibility was maintained even after normalization of the gut microbiome. EL-Abx decreased systemic levels of indole-3-propionic acid (IPA), which induced long-term changes to cellular stress, metabolism, and mitochondrial respiration in the lung epithelium. IPA reduced mitochondrial respiration and superoxide production and altered chemokine and cytokine production. Consequently, early-life IPA supplementation protected EL-Abx mice against exacerbated HDM-induced allergic airway inflammation in adulthood. These results reveal a mechanism through which EL-Abx can predispose the lung to allergic airway inflammation and highlight a possible preventative approach to mitigate the detrimental consequences of EL-Abx.
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