蛋白质水解
生物
生物技术
人口
计算生物学
生物化学
医学
酶
环境卫生
作者
Qi Xu,Hao Feng,Zhong Li,Xusheng Shao
标识
DOI:10.1021/acs.jafc.4c02793
摘要
Novel approaches for pest control are essential to ensure a sufficient food supply for the growing global population. The development of new insecticides must meet rigorous regulatory requirements for safety and address the resistance issues of existing insecticides. Proteolysis-targeting chimeras (PROTACs), originally developed for human diseases, show promise in agriculture. They offer innovative insecticides tailored to overcome resistance, opening avenues for agricultural applications. In this study, we developed small-molecule degraders by incorporating pomalidomide as an E3 ligand. These degraders were linked to a ligand (spirotetratmat enol) targeting the ACC protein through a flexible chain, aiming to achieve the efficient control of insects. Compounds
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