Facile synthesis of mesoporous zinc oxide nanoparticle as a drug delivery system evaluated by IVIVE in PBPK modeling

药物输送 纳米颗粒 聚乙二醇 材料科学 化学工程 结晶度 介孔材料 PEG比率 动力学 核化学 化学 纳米技术 有机化学 物理 财务 量子力学 工程类 经济 复合材料 催化作用
作者
Koushi Kumar,Nirmala Nithya Raju,Abdul Azeez Nazeer
出处
期刊:Advances in Natural Sciences: Nanoscience and Nanotechnology [IOP Publishing]
卷期号:15 (3): 035009-035009
标识
DOI:10.1088/2043-6262/ad6cc3
摘要

Abstract This study focuses on the development of mesoporous zinc oxide nanoparticles (mZNPs) via the sol–gel technique, utilizing polyethylene glycol-6000 (PEG-6000) as a capping agent. The research aims to investigate the suitability of these nanoparticles for drug delivery purposes. The analysis of the synthesized material validates the existence of a hexagonal system of zinc oxide with space group P6 3 cm and HRTM confirmed the crystallinity and morphology of the nanoparticles ranging from 15–20 nm, revealing the formation of pores attributed to the presence of PEG-6000. The mZNPs exhibit a BET surface area of 28.3 m 2 . g −1 , with Langmuir surface area measurements indicating 46 m 2 . g −1 . Analysis employing the BJH method outlines pore diameters ranging from approximately 2–5 nm at a relative pressure of around 0.99. Furthermore, these mZNPs demonstrated drug delivery attributes, with 43.3% loading efficiency and 80.33% entrapment efficiency for aspirin. Notably, the release kinetics of aspirin from the mZNPs were investigated in simulated fluids of varying pH, with the highest release (98.1%) observed in simulated intestinal fluid (pH 6.8). The formulation exhibits typical time-dependent release kinetics under mild pH conditions (7.4 and 6.8), while transitioning to erosion-controlled diffusion mechanisms in acidic pH conditions (1.2). Furthermore, mathematical models, including Higuchi’s, Korsmeyer’s, and Weibull’s, were employed to assess release kinetics, offering parameters for in-vitro to in-vivo pharmacokinetic predictions. In the framework of PBPK modeling, renal clearance was computationally simulated at a rate of 45 min −1 , whereas biliary clearance was modeled to occur at 0.05 min −1 . Utilizing these model-derived parameters, the projected half-life of aspirin administered via mZNPs was determined to be 3.1 h. The potential applications of these findings extend to the development of effective drug delivery systems, warranting consideration for future animal model studies involving aspirin and mZNPs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
共享精神应助于航采纳,获得10
1秒前
小海发布了新的文献求助10
1秒前
2秒前
2秒前
5秒前
Orange应助爱听歌的紫菜采纳,获得10
5秒前
6秒前
灰灰灰发布了新的文献求助10
6秒前
背后访风发布了新的文献求助10
6秒前
研友_VZG7GZ应助Muttu采纳,获得10
7秒前
8秒前
9秒前
淀粉肠发布了新的文献求助20
9秒前
朴实初夏完成签到 ,获得积分10
9秒前
9秒前
arui完成签到,获得积分10
9秒前
10秒前
科研通AI2S应助认真学习采纳,获得10
11秒前
糖果屋发布了新的文献求助10
11秒前
11冰之泪发布了新的文献求助30
12秒前
Rjy发布了新的文献求助10
14秒前
灰灰灰完成签到,获得积分10
15秒前
小鱼发布了新的文献求助10
17秒前
bkagyin应助超级小熊猫采纳,获得10
17秒前
17秒前
..关闭了..文献求助
21秒前
认真学习完成签到,获得积分20
21秒前
Muttu发布了新的文献求助10
21秒前
冷艳贵公子王少完成签到,获得积分10
21秒前
22秒前
23秒前
26秒前
爱听歌的紫菜完成签到,获得积分10
26秒前
zp560完成签到,获得积分10
27秒前
27秒前
学术蝗虫完成签到 ,获得积分10
27秒前
迷人素完成签到 ,获得积分10
28秒前
蓝桥易乞发布了新的文献求助10
29秒前
糖果屋完成签到,获得积分10
29秒前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Le dégorgement réflexe des Acridiens 800
Defense against predation 800
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3136127
求助须知:如何正确求助?哪些是违规求助? 2787029
关于积分的说明 7780244
捐赠科研通 2443154
什么是DOI,文献DOI怎么找? 1298899
科研通“疑难数据库(出版商)”最低求助积分说明 625294
版权声明 600870