作者
Pavla Boháčová,Marina Terekhova,Petr Tsurinov,Riley Mullins,Kamila Husarcikova,Irina Shchukina,Alina Ulezko Antonova,Barbora Echalar,Jan Kössl,A.Y. Saidu,Thomas Francis,Chelsea Mannie,Laura Arthur,Stephen D. R. Harridge,Daniel Kreisel,Philip A. Mudd,Angela M. Taylor,Coleen A. McNamara,Marina Cella,Sidharth V. Puram,Theo van den Broek,Femke van Wijk,Pirooz Eghtesady,Maxim N. Artyomov
摘要
Thymic involution is a key factor in human immune aging, leading to reduced thymic output and a decline in recent thymic emigrant (RTE) naive T cells in circulation. Currently, the precise definition of human RTEs and their corresponding cell surface markers lacks clarity. Analysis of single-cell RNA-seq/ATAC-seq data distinguished RTEs by the expression of SOX4, IKZF2, and TOX and CD38 protein, whereby surface CD38