医学
再狭窄
传统PCI
经皮冠状动脉介入治疗
冠状动脉疾病
西罗莫司
血管成形术
介入心脏病学
支架
气球
药物洗脱支架
心脏病学
紫杉醇
导管
内科学
心肌梗塞
放射科
化疗
作者
Nicola Verde,Giuseppe Ciliberti,L Pittorino,Marco Ferrone,Michele Franzese,Massimo Russo,Angelo Cioppa,Grigore Popusoi,Luigi Salemme,Tullio Tesorio,Giuseppe Di Gioia
摘要
The interventional treatment of coronary artery disease (CAD) has undergone significant improvements thanks to technological innovations. Nowadays, percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation is the standard of care for the treatment of CAD. Nevertheless, the non-negligible incidence of in-stent restenosis (ISR) and suboptimal results in various anatomical settings has led to the development of drug-coated balloons (DCBs). DCBs are catheter-based balloons whose surface is coated with an anti-proliferative drug (mainly Paclitaxel or Sirolimus) loaded onto the balloon surface with different technologies and dose concentrations. In the beginning, these devices were used for the treatment of ISR showing an excellent efficacy profile in the inhibition of intimal hyperplasia. Subsequently, several studies evaluated their use in other angiographical and clinical contexts such as de novo lesions, small vessel disease, diffuse coronary disease, bifurcation lesions, acute coronary syndromes, high-bleeding risk and diabetic patients. This comprehensive review aims to describe the main DCB platforms on the market, their fields of application with the main supporting studies and their future perspectives.
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