再生(生物学)
软骨
计算机科学
细胞生物学
生物
解剖
作者
Zhan Su,Yang Tan,Xinchen Wu,Peiran Liu,Yisimayili Nuermaimaiti,Yuping Ran,Peng Wang,Pinyin Cao
出处
期刊:Tissue Engineering Part B-reviews
[Mary Ann Liebert]
日期:2024-07-26
标识
DOI:10.1089/ten.teb.2024.0140
摘要
Cartilage tissue, encompassing hyaline cartilage, fibrocartilage, and elastic cartilage, plays a pivotal role in the human body due to its unique composition, structure, and biomechanical properties. However, the inherent avascularity and limited regenerative capacity of cartilage present significant challenges to its healing following injury. This review provides a comprehensive analysis of the current state of cartilage tissue engineering, focusing on the critical components of cell sources, scaffolds, and growth factors tailored to the regeneration of each cartilage type.We explore the similarities and differences in the composition, structure, and biomechanical properties of the three cartilage types and their implications for tissue engineering. A significant emphasis is placed on innovative strategies for cartilage regeneration, including the potential for in situ transformation of cartilage types through microenvironmental manipulation, which may offer novel avenues for repair and rehabilitation.The review underscores the necessity of a nuanced approach to cartilage tissue engineering, recognizing the distinct requirements of each cartilage type while exploring the potential of transforming one cartilage type into another as a flexible and adaptive repair strategy. Through this detailed examination, we aim to broaden the understanding of cartilage tissue engineering and inspire further research and development in this promising field.
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