内质网
草酸钙
细胞质
细胞生物学
肾
肾结石
细胞外
小管
未折叠蛋白反应
化学
钙
生物
医学
内科学
内分泌学
作者
Lei Zhang,Simin Li,Minghui Cong,Zhuoya Liu,Zhiyue Dong,Meng Zhao,Kun Gao,Lihong Hu,Hongzhi Qiao
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-02-02
卷期号:23 (4): 1555-1563
被引量:17
标识
DOI:10.1021/acs.nanolett.2c05099
摘要
Kidney stones, represented by the calcium oxalate (CaOx) type, are highly prevalent and recrudescent. Cumulative evidence shows regular consumption of lemonade intervenes with stone development. However, the detailed mechanism remains obscure. Here, extracellular vesicle-like nanoparticles (LEVNs) isolated from lemonade are demonstrated to traffick from the gut to the kidney, primarily enriched in tubule cells. Oral administration of LEVNs significantly alleviates the progression of kidney stones in rats. Mechanistically, in addition to altering the crystallization of CaOx toward a less stable subtype, LEVNs suppress the CaOx-induced endoplasmic reticulum stress response of tubule cells, as indicated by homeostasis of specific signaling molecules and restoration of subcellular function, thus indirectly inhibiting stone formation. To exercise this regulation, endocytosed LEVNs traffick along the microtubules throughout the cytoplasm and are eventually recruited into lysosomes. In conclusion, this study reveals a LEVNs-mediated mechanism against renal calculi and provides positive evidence for consumption of lemonade preventing stone formation.
科研通智能强力驱动
Strongly Powered by AbleSci AI