Alterations in the human oral microbiota in systemic lupus erythematosus

医学 免疫学 系统性红斑狼疮 皮肤病科 病理 疾病
作者
Jinyan Guo,Guangying Cui,Wei Huang,Zhaohui Zheng,Tianfang Li,Guanmin Gao,Zhen Huang,Yuwei Zhan,Suying Ding,Shengyun Liu,Zujiang Yu,Zhigang Ren
出处
期刊:Journal of Translational Medicine [BioMed Central]
卷期号:21 (1) 被引量:10
标识
DOI:10.1186/s12967-023-03892-3
摘要

Abstract Background Alterations in oral microbiota in patients with systemic lupus erythematosus (SLE) is less evaluated. The aim of this study was to compare the characteristics of the oral microbiome in SLE patients and healthy controls, and construct an SLE classifier based on the oral microbiota. Methods We sequenced tongue-coating samples of individuals in treatment-naïve SLE (n = 182) and matched healthy controls (n = 280). We characterized the oral microbiome and constructed a microbial classifier in the derivation cohort and validated the results in the validation cohorts. Furthermore, the oral microbiome of posttreatment SLE (n = 73) was characterized. Results The oral microbial diversity of SLE was increased, and the microbial community was different between SLE and healthy controls. The genera Prevotella and Veillonella were enriched, while Streptococcus and Porphyromonas were reduced in SLE. In addition, an increase was noted in 27 predicted microbial functions, while a decrease was noted in 34 other functions. Thirty-nine operational taxonomy units (OTUs) were identified to be related with seven clinical indicators. Two OTUs were identified to construct a classifier, which yielded area under the curve values of 0.9166 (95% CI 0.8848–0.9483, p < 0.0001), 0.8422 (95% CI 0.7687–0.9157, p < 0.0001), and 0.8406 (95% CI 0.7677–0.9135, p < 0.0001) in the derivation, validation, and cross-regional validation groups, respectively. Moreover, as disease activity increased, Abiotrophia and Lactobacillales increased, while Phyllobacterium and unclassified Micrococcusaceae decreased. Finally, nine OTUs were selected to construct a classifier distinguishing posttreatment SLE patients from healthy controls, which achieved a diagnostic efficacy of 0.9942 (95% CI 0.9884–1, p < 0.0001). Conclusions Our study comprehensively characterizes the oral microbiome of SLE and shows the potential of the oral microbiota as a non-invasive diagnostic biomarker in SLE.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
zhouzhou完成签到,获得积分10
1秒前
1秒前
xmuchem发布了新的文献求助10
2秒前
2秒前
2秒前
木木发布了新的文献求助10
2秒前
诚心钢铁侠完成签到,获得积分10
2秒前
大个应助正太低音炮采纳,获得10
4秒前
4秒前
上进发布了新的文献求助10
5秒前
Ava应助BinSir采纳,获得10
5秒前
啦啦啦啦发布了新的文献求助10
5秒前
alex发布了新的文献求助10
5秒前
6秒前
6秒前
6秒前
6秒前
元哥发布了新的文献求助10
6秒前
cocobear完成签到 ,获得积分10
6秒前
xiao67er完成签到,获得积分20
7秒前
7秒前
7秒前
超帅鸣凤发布了新的文献求助10
7秒前
8秒前
9秒前
9秒前
9秒前
深情安青应助坚强幼晴采纳,获得10
10秒前
xia_完成签到,获得积分10
10秒前
酷酷的泥猴桃完成签到,获得积分10
10秒前
充电宝应助儒雅的娩采纳,获得10
10秒前
ning发布了新的文献求助10
10秒前
朴实夏旋发布了新的文献求助10
10秒前
10秒前
plant发布了新的文献求助10
11秒前
12秒前
缓慢代亦发布了新的文献求助10
13秒前
22222发布了新的文献求助10
14秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Social Research Methods (4th Edition) by Maggie Walter (2019) 2390
A new approach to the extrapolation of accelerated life test data 1000
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4009871
求助须知:如何正确求助?哪些是违规求助? 3549812
关于积分的说明 11303839
捐赠科研通 3284342
什么是DOI,文献DOI怎么找? 1810591
邀请新用户注册赠送积分活动 886393
科研通“疑难数据库(出版商)”最低求助积分说明 811406