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The association between HDL‐C and stroke in the middle‐aged and elderly: A cross‐sectional study

医学 冲程(发动机) 横断面研究 优势比 置信区间 内科学 人口学 流行病学 多元分析 全国健康与营养检查调查 贝叶斯多元线性回归 老年学 回归分析 人口 病理 环境卫生 机械工程 社会学 工程类 机器学习 计算机科学
作者
Yang Hu,Min Sup Song,Dongmei Wu,Yuqing Zhang,Gongbo Li,Haiyan Luo
出处
期刊:Brain and behavior [Wiley]
卷期号:13 (3) 被引量:2
标识
DOI:10.1002/brb3.2901
摘要

Abstract Background Previous epidemiological studies have indicated that high‐density lipoprotein cholesterol (HDL‐C) is inversely associated with the risk of cardiovascular disease. However, this issue has aroused controversy in recent years. Besides, the relationship between HDL‐C and the risk of total stroke in sex and race is less clear. Thus, we aimed to examine the association between different ranges of HDL‐C and the risk of total stroke in adults over 40 years old. Methods This cross‐sectional study was conducted on a sample of 8643 participants (4222 men and 4421 women) aged ≥40 years old from the National Health and Nutrition Examination Survey 2007–2016. HDL‐C was an independent variable and stroke was a dependent variable in this study, with the other variables as potential effect modifiers. To examine the associations between them, we used multivariate logistical regression models and smooth curve fittings, as well as subgroup analyses. Results HDL‐C was inversely associated with stroke when HDL‐C was less than 1.55 mmol/L (odds ratio [OR] = 0.36, 95% confidence interval [CI] :0.21–0.62, p < .05). However, above 1.55 mmol/L, the incidence of stroke was not significant (OR = 1.29, 95% CI: 0.79–2.09, p >.05). Stratified by race/ethnicity and sex, the subgroup analyses demonstrated that HDL‐C was inversely associated with stroke in men and Whites, but no significant differences among women, Mexicans, blacks, and other races. Conclusion We found a nonlinear relationship between HDL‐C and total stroke. Our study reveals a range of inverse associations between HDL‐C and stroke (HDL‐C<1.55 mmol/L), especially among men and Whites. This finding suggested that maintaining an appropriate HDL‐C range may be beneficial in reducing the incidence of stroke.
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