Chiral Self‐Sorting in Pd6L12 Metal‐Organic Cages

Abstract Chiral self‐sorting during the formation of cage‐like molecules continues to fascinate and advance our understanding of the phenomenon in general. Herein, we report the chiral self‐sorting in the Pd 6 L 12 ‐type metal‐organic cages. When a racemic mixture of axially chiral bis‐pyridyl ligands undergo coordination‐driven self‐assembly with Pd(II) ions to form Pd 6 L 12 ‐type cages, the system has the option of chiral self‐sorting to afford any of at least 70 pairs of (one homochiral and 69 heterochiral) enantiomers and 5 meso isomers or a statistical mixture of everything. However, the system resulted in diastereoselective self‐assembly through a high‐fidelity chiral social self‐sorting to form a racemic mixture of D 3 symmetric heterochiral [Pd 6 ( L 6 R/6S ) 12 ] 12+ /[Pd 6 ( L 6 S/6R ) 12 ] 12+ cages.