Transition metal-catalyzed asymmetric three-component dicarbofunctionalization of unactivated alkenes

Significant advances have been made in the catalytic dicarbofunctionalization of alkenes in recent years. However, the development of the highly enantioselective dicarbofunctionalization of alkenes using transition-metal catalysts is limited. The merits of the newly generated chiral sp3-hybridized carbon centers in natural products, pharmaceutical ingredients, and many other classes of compounds have led to the rapid development of the asymmetric dicarbofunctionalization of alkenes. This perspective summarizes the recent developments in various metal-catalyzed asymmetric dicarbofunctionalizations of unactivated alkenes and highlights the remaining challenges and possible opportunities in this growing field.