Quantification of the Relationship of Pyridoxine and Spirometry Measurements in the United States Population

There has been evidence to suggest associations between vitamins and lung function. The study aimed to examine the association between Vitamin B6 and spirometry values. A retrospective study was done using NHANES 2007-2012, which is a nationally representative, modern cohort. Spirometry, a clinical pulmonary function test measured the amount and speed of air a person could exhale after taking the deepest possible breath after forceful exhalation at 1 second (FEV1) and total exhaled volume of air (FVC). After determination of relationship of the linearity of variables, univariable and multivariable models were fit to investigate the effect of Vitamin B6 on FEV1 and FVC. The National Center for Health Statistics Ethics Review Board granted permission for the study's data collection and analysis. Of 19,160 individuals that had complete information on Vitamin B6 intake, FEV1, and FVC, it was found each mg of Vitamin B6 intake was associated with increase in 166.41 mL (95% CI: 156.71-176.12, p<0.01) of FEV1 and 221.6 mL of FVC (95% CI: 209.62-233.57, p<0.01). After controlling for potential confounders (age, race, sex, BMI, education, and income), multiple linear regression found that Vitamin B6 each mg of Vitamin B6 was associated with increase in 25.98 mL (95% CI: 19.15-32.80, p<0.01) of FEV1 and 38.97 mL of FVC (95% CI: 30.65-47.30, p<0.01). Increased Vitamin B6 intake is associated with improvement in lung function. Further prospective studies are required to ascertain whether increased Vitamin B6 can lead to increased long term spirometry measurements and the specific therapeutic dose-response relationship.