DRP1-Mediated Mitophagy: Safeguarding Obese Hearts From Cardiomyopathy

HomeCirculation ResearchVol. 133, No. 1DRP1-Mediated Mitophagy: Safeguarding Obese Hearts From Cardiomyopathy No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextDRP1-Mediated Mitophagy: Safeguarding Obese Hearts From Cardiomyopathy Xi Fang and Åsa B. Gustafsson Xi FangXi Fang https://orcid.org/0000-0001-7816-8821 Department of Medicine (X.F.), University of California San Diego, La Jolla, CA. Search for more papers by this author and Åsa B. GustafssonÅsa B. Gustafsson Correspondence to: Åsa B. Gustafsson, PhD, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Dr, Mail Code 0657, La Jolla, CA 92093. Email E-mail Address: [email protected] https://orcid.org/0000-0001-6347-8210 Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences (Å.B.G.), University of California San Diego, La Jolla, CA. Search for more papers by this author Originally published22 Jun 2023https://doi.org/10.1161/CIRCRESAHA.123.323013Circulation Research. 2023;133:22–24This article is a commentary on the followingDistinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity CardiomyopathyFootnotesFor Sources of Funding and Disclosures, see page 24.The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Correspondence to: Åsa B. Gustafsson, PhD, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Dr, Mail Code 0657, La Jolla, CA 92093. Email abgustafsson@health.ucsd.eduReferences1. Abel ED. Obesity stresses cardiac mitochondria even when you are young.J Am Coll Cardiol. 2011; 57:586–589. doi: 10.1016/j.jacc.2010.09.039CrossrefMedlineGoogle Scholar2. Kubli DA, Gustafsson AB. Unbreak my heart: targeting mitochondrial autophagy in diabetic cardiomyopathy.Antioxid Redox Signal. 2015; 22:1527–1544. doi: 10.1089/ars.2015.6322CrossrefMedlineGoogle Scholar3. Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, et al. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy.EMBO J. 2008; 27:433–446. doi: 10.1038/sj.emboj.7601963CrossrefMedlineGoogle Scholar4. Moyzis A, Gustafsson AB. Multiple recycling routes: canonical vs. non-canonical mitophagy in the heart.Biochim Biophys Acta Mol Basis Dis. 2019; 1865:797–809. doi: 10.1016/j.bbadis.2018.09.034CrossrefMedlineGoogle Scholar5. Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A, Sadoshima J. Mitophagy is essential for maintaining cardiac function during high fat diet-induced diabetic cardiomyopathy.Circ Res. 2019; 124:1360–1371. doi: 10.1161/CIRCRESAHA.118.314607LinkGoogle Scholar6. Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A, Sadoshima J. Alternative mitophagy protects the heart against obesity-associated cardiomyopathy.Circ Res. 2021; 129:1105–1121. doi: 10.1161/CIRCRESAHA.121.319377LinkGoogle Scholar7. Tong M, Mukai R, Mareedu S, Zhai P, Oka S, Huang C, Hsu C, Yousufzai F, Fritzky L, Mizushima W, et al. The roles of DRP1 in mitophagy during obesity cardiomyopathy.Circ Res. 2023; 133:6–21. doi: 10.1161/CIRCRESAHA.123.322512LinkGoogle Scholar8. Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K, Egashira K, Ohishi M, et al. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress.Circ Res. 2015; 116:264–278. doi: 10.1161/CIRCRESAHA.116.303356LinkGoogle Scholar9. Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B, Sadoshima J. Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure.Circulation. 2016; 133:1249–1263. doi: 10.1161/CIRCULATIONAHA.115.020502LinkGoogle Scholar10. Kageyama Y, Hoshijima M, Seo K, Bedja D, Sysa-Shah P, Andrabi SA, Chen W, Hoke A, Dawson VL, Dawson TM, et al. Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain.EMBO J. 2014; 33:2798–2813. doi: 10.15252/embj.201488658CrossrefMedlineGoogle Scholar11. Quiles JM, Najor RH, Gonzalez E, Jeung M, Liang W, Burbach SM, Zumaya EA, Diao RY, Lampert MA, Gustafsson AB. Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy.Sci Signal. 2023; 16:eabo4457. doi: 10.1126/scisignal.abo4457CrossrefMedlineGoogle Scholar12. Germain M, Mathai JP, McBride HM, Shore GC. Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.EMBO J. 2005; 24:1546–1556. doi: 10.1038/sj.emboj.7600592CrossrefMedlineGoogle Scholar13. Koch A, Thiemann M, Grabenbauer M, Yoon Y, McNiven MA, Schrader M. Dynamin-like protein 1 is involved in peroxisomal fission.J Biol Chem. 2003; 278:8597–8605. doi: 10.1074/jbc.M211761200CrossrefMedlineGoogle Scholar eLetters(0) eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate. Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page. Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesDistinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity CardiomyopathyMingming Tong, et al. Circulation Research. 2023;133:6-21 June 23, 2023Vol 133, Issue 1 Advertisement Article Information Metrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.123.323013PMID: 37347834 Originally publishedJune 22, 2023 KeywordsEditorialcardiovascular diseasesheartmitochondria, mitophagyobesityPDF download Advertisement