Photo Energy Transfer-Enabled Thiosulfinylation of Alkynes for Asymmetric Synthesis of Sultims

An asymmetric and highly practical thiosulfinylation of alkynes is established for the synthesis of sultim derivatives. The disclosed platform featured broad substrate scope and group tolerance for diverse biologically important molecules under mild and operationally simple conditions. Notably, the obtained chiral sulfinyl derivatives have demonstrated their potential application in further gram-scale synthesis and product derivatizations, providing a chance for drug discovery.