Sustainable agriculture has developed recently, increasing the need for new technological expansions to decrease the use of chemical fertilizers and pesticides that harm the environment. Hence the relevance of nanotechnology, which boosts the potential of plants to take in nutrients, enhances the characteristics of agricultural soil to resume its fertility, and increases plant growth with improved productivity to meet the food requirements for a growing population. In the same direction, probiotic microbes have a remarkable role in the productivity of crops in a secure and nutritious way. Not only does the use of diverse, useful microbes in agriculture decrease the utilization of artificial fertilizers, it also supports biohealthy agriculture. The useful microbes ameliorate nutrient availability, reduce infection with pathogens, and promote impedance to abiotic stresses such as drought and salinity. Consequently, the primary goal of sustainable agriculture is environmental health, social and economic justice, and economic viability, which can be achieved by adding plant probiotics using nanotechnology. The presence of nanoparticles supports a new green upheaval and minimizes the hazards of traditional farming.