抗菌剂
光热治疗
伤口愈合
自愈
药物输送
纳米技术
共价键
化学
脚手架
生物医学工程
材料科学
医学
有机化学
外科
替代医学
病理
作者
Fatemeh Mohajer,Ghodsi Mohammadi Ziarani,Алиреза Бадией,Siavash Iravani,Rajender S. Varma
出处
期刊:RSC Advances
[The Royal Society of Chemistry]
日期:2023-01-01
卷期号:13 (12): 8136-8152
被引量:11
摘要
Covalent organic frameworks (COFs) are crystal-like organic structures such as cartography buildings prepared from appropriately pre-designed construction block precursors. Moreover, after the expansion of the first COF in 2005, numerous researchers have been developing different materials for versatile applications such as sensing/imaging, cancer theranostics, drug delivery, tissue engineering, wound healing, and antimicrobials. COFs have harmonious pore size, enduring porosity, thermal stability, and low density. In addition, a wide variety of functional groups could be implanted during their construction to provide desired constituents, including antibodies and enzymes. The reticular organic frameworks comprising porous hybrid materials connected via a covalent bond have been studied for improving wound healing and dressing applications due to their long-standing antibacterial properties. Several COF-based systems have been planned for controlled drug delivery with wound healing purposes, targeting drugs to efficiently inhibit the growth of pathogenic microorganisms at the wound spot. In addition, COFs can be deployed for combinational therapy using photodynamic and photothermal antibacterial therapy along with drug delivery for healing chronic wounds and bacterial infections. Herein, the most recent advancements pertaining to the applications of COF-based systems against bacterial infections and for wound healing are considered, concentrating on challenges and future guidelines.
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